Hypoxia-inducible factors and their roles in energy metabolism
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چکیده
منابع مشابه
Hypoxia-inducible transcription factors and their role in renal disease.
The 2 hypoxia inducible factors (HIF)-1alpha and HIF-2alpha are key mediators of cellular adaptation to hypoxia. They show a specific distribution pattern and possibly have complementary transcriptional targets in the kidney: HIF-1alpha is found mainly in tubular and HIF-2alpha in peritubular interstitial, endothelial, and glomerular cells. Both isoforms are regulated by oxygen-dependent hydrox...
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Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining...
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ژورنال
عنوان ژورنال: International Journal of Hematology
سال: 2012
ISSN: 0925-5710,1865-3774
DOI: 10.1007/s12185-012-1069-y